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Institute for Basic Science




1. Ko HG, Lee SJ, Son H, Kaang BK, 2007: Null effect of antidepressants on the astrocytes-mediated proliferation of hippocampal progenitor cells in vitro. Mol Pain, 3,16

2. Lee SH, Lim CS, Park H, Lee JA, Han JH, Kim H, Cheang YH, Lee SH, Lee YS, Ko HG, Jang DH, Kim H, Miniaci MC, Bartsch D, Kim E, Bailey CH, Kandel ER, Kaang BK, 2007: Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia. Cell, 129(4),801-12

3. Shum FW, Wu LJ, Zhao MG, Toyoda H, Xu H, Ren M, Pinaud R, Ko SW, Lee YS, Kaang BK, Zhuo M, 2007: Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learn Mem, 14(4),304-12

4. Wang H, Gong B, Vadakkan KI, Toyoda H, Kaang BK, Zhuo M, 2007: Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors. J Bio Chem, 282(2),1507-17

5. Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, Jia Z, Kaang BK, Kawamata M, Kida S, Klann E, 2006: Recent advances in basic neurosciences and brain disease: from synapses to behavior. Mol Pain, 2,38 

6. Lee JA, Lee SH, Lee C, Chang DJ, Lee Y, Kim H, Cheang YH, Ko HG, Lee YS, Jun H, Bartsch D, Kandel ER, Kaang BK, 2006: PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation. J Cell Biol, 174(6),827-38 

7. Yim SJ, Lee YS, Lee JA, Chang DJ, Han JH, Kim H, Park H, Jun H, Kim VN, Kaang BK, 2006: Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation. J Neurochem, 98(2),420-9 

8. Ko SW, Jia Y, Xu H, Yim SJ, Jang DH, Lee YS, Zhao MG, Toyoda H, Wu LJ, Chatila T, Kaang BK, Zhuo M, 2006: Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. Eur J Neurosci, 23(8),2158-68 

9. Ko J, Kim S, Chung HS, Kim K, Han K, Kim H, Jun H, Kaang BK, Kim E, 2006: SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses. Neuron, 50(2),233-45 

10. Kim H, Lee SH, Han JH, Lee JA, Cheang YH, Chang DJ, Lee YS, Kaang BK, 2006: A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in aplysia neurons. Neuron, 49(5),707-18  
11. Kim JH, Lee JA, Song YM, Park CH, Hwang SJ, Kim YS, Kaang BK, Son H, 2006: Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth. FASEB J, 20(1),109-11 
12. Jang DH, Han JH, Lee SH, Lee YS, Park H, Lee SH, Kim H, Kaang BK, 2005: Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses. Proc Natl Acad Sci U S A, 102(44),16072-7  

13. Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M, 2005: Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci, 25(48),11107-16  

14. Park H, Lee JA, Lee C, Kim MJ, Chang DJ, Kim H, Lee SH, Lee YS, Kaang BK, 2005: An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation. J Neurosci, 25(39),9037-45  

15. Zhao MG, Toyoda H, Lee YS, Wu LJ, Ko SW, Zhang XH, Jia Y, Shum F, Xu H, Li BM, Kaang BK, Zhuo M, 2005: Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron, 47(6),859-72  

16. Han JH, Lee C, Cheang Y, Kaang BK, 2005: Suppression of long-term facilitation by Rab3-effector protein interaction. Mol Res Mol Brain Res, 139(1),13-22  

17. Shum FW, Ko SW, Lee YS, Kaang BK, Zhuo M, 2005: Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV. Mol Pain, 1,22  

18. Lee Y, Lee Y, Lee J, Bang S, Hyun S, Kang J, Hong ST, Bae E, Kaang BK, Kim J, 2005: Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster. Nat Genet, 37(3),305-10  

19. Gong Z, Son W, Chung YD, Kim J, Shin DW, McClung CA, Lee Y, Lee HW, Chang DJ, Kaang BK, Cho H, Oh U, Hirsh J, Kernan MJ, Kim C, 2004: Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. J Neurosci, 24(41),9059-66  

20. Han JH, Lim CS, Lee YS, Kandel ER, Kaang BK, 2004: Role of Aplysia cell adhesion molecules during 5-HT-induced long-term functional and structural changes. Learn Mem, 11(4),421-35  

21. Chang DJ, Lee SH, Lim CS, Jang DH, Lee CH, Lee YD, Kaang BK, 2004: Thiol oxidation-mediated cell death in Aplysia cultured sensory neurons. Brain Res, 1007(1-2),71-7  

22. Akalal DB, Bottenstein JE, Lee SH, Han JH, Chang DJ, Kaang BK, Nagle GT, 2003: Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system. Brain Res Mol Brain Res, 117(2),228-36  

23. Lee Y, Han JH, Lim CS, Chang DJ, Lee YS, Soh H, Park CS, Kaang BK, 2003: Impairment of a parabolic bursting rhythm by the ectopic expression of a small conductance Ca2+-activated K+ channel in Aplysia neuron R15. Neurosci Lett, 349(1),53-7  

24. Lee Y, Chang DJ, Lee YS, Chang KA, Kim H, Yoon JS, Lee S, Suh YH, Kaang BK, 2003: Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system. J Neurosci Res, 73(2),255-9  

25. Kim H, Chang DJ, Lee JA, Lee YS, Kaang BK, 2003: Identification of nuclear/nucleolar localization signal in Aplysia learning associated protein of slug with a molecular mass of 18 kDa homologous protein. Neurosci Lett, 343(2),134-8  

26. Son H, Yu IT, Hwang SJ, Kim JS, Lee SH, Lee YS, Kaang BK, 2003: Lithium enhances long-term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus. J Neurochem, 85(4),872-81  

27. Lee JA, Lim CS, Lee SH, Kim H, Nukina N, Kaang BK, 2003: Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons. J Neurochem, 85(1),160-9 

28. Chang DJ, Lim CS, Lee SH, Kaang BK, 2003: Hydrogen peroxide modulates K+ ion currents in cultured Aplysia sensory neurons. Brain Res, 970(1-2),159-68  

29. Huh M, Han JH, Lim CS, Lee SH, Kim S, Kim E, Kaang BK, 2003: Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons. J Neurochem, 85(1),282-5  

30. Chang DJ, Lim CS, Lee JA, Kaang BK, 2003: Synaptic facilitation by ectopic octopamine and 5-HT receptors in Aplysia. Brain Res Bull, 60(1-2),73-9  

31. Lee SH, Han JH, Choi JH, Huh EY, Kwon YK, Kaang BK, 2003: The effect of brain-derived neurotrophic factor on neuritogenesis and synaptic plasticity in Aplysia neurons and the hippocampal cell line HiB5. Mol Cells, 15(2),233-9 

32. Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E, 2003: The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. J Bio Chem, 278(8),6291-300  

33. Lee JA, Kim H, Lee YS, Kaang BK, 2003: Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein-2, a repressor of long-term facilitation, in Aplysia kurodai sensory-to-motor synapses. Neurosci Lett, 337(1),9-12  

34. Choi JH, Lee JA, Yim SW, Lim CS, Lee CH, Lee YD, Bartsch D, Kandel ER, Kaang BK, 2003: Using an aplysia two-hybrid system to examine the interactions between transcription factors involved in long-term facilitation in the nervous system of aplysia. Learn Mem, 10(1),40-3  

35. Kim MJ, Chang DJ, Lim CS, Park WJ, Kaang BK, 2003: Screening of cDNA encoding secreted and membrane proteins in the nervous system of Aplysia. Korean J Biol Sci, 7(2),133

36. Lim CS, Lee JC, Kim SD, Chang DJ, Kaang BK, 2002: Hydrogen peroxide-induced cell death in cultured Aplysia sensory neurons. Brain Res, 941(1-2),137-45  

37. Suh SJ, Park YS, Lee YS, Cho TJ, Kaang BK, Cho NJ, 2001: Three functional isoforms of GAR-2, a Caenorhabditis elegans G-protein-linked acetylcholine receptor, are produced by alternative splicing. Biochem Biophys Res Commun, 288(5),1238-43  

38. Lee JA, Kim HK, Kim KH, Han JH, Lee YS, Lim CS, Chang DJ, Kubo T, Kaang BK, 2001: Overexpression of and RNA interference with the CCAAT enhancer-binding protein on long-term facilitation of Aplysia sensory to motor synapses. Learn Mem, 8(4),220-6  

39. Lee YS, Park YS, Nam S, Suh SJ, Lee J, Kaang BK, Cho NJ, 2000: Characterization of GAR-2, a novel G protein-linked acetylcholine receptor from Caenorhabditis elegans. J Neurochem, 75(5),1800-9  

40. Myeong H, Jeoung D, Kim H, Ha JH, Lee Y, Kim KH, Park C, Kaang BK, 2000: Genomic analysis and functional expression of canine dopamine D2 receptor. Gene, 257(1),99-107  

41. Lee YS, Lee JA, Jung J, Oh U, Kaang BK, 2000: The cAMP-dependent kinase pathway does not sensitize the cloned vanilloid receptor type 1 expressed in xenopus oocytes or Aplysia neurons. Neurosci Lett, 288(1),57-60  

42. Chang DJ, Li XC, Lee YS, Kim HK, Kim US, Cho NJ, Lo X, Weiss KR, Kandel ER, Kaang BK, 2000: Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in aplysia sensory neurons. Proc Natl Acad Sci U S A, 97(4),1829-34  

43. Park YS, Lee YS, Cho NJ, Kaang BK, 2000: Alternative splicing of gar-1, a Caenorhabditis elegans G-protein-linked acetylcholine receptor gene. Biochem Biophys Res Commun, 268(2),354-8  

44. Han JH, Yim SW, Lim CS, Park CW, Kaang BK, 1999: Expression of a non-inactivating Kchannel driven by a rat heat shock promoter increased the resting potential in Aplysia silent neurons. Neurosci Res, 34(1),13-9  

45. Lee YS, Park YS, Chang DJ, Hwang JM, Min CK, Kaang BK, Cho NJ, 1999: Cloning and Expression of a G Protein-Linked Acetylcholine Receptor from Caenorhabditis elegans. J Neurochem, 72(1),58-65  

46. Hwang JM, Chang DJ, Kim US, Lee YS, Park YS, Kaang BK, Cho NJ, 1999: Cloning and functional characterization of a Caenorhabditis elegans muscarinic acetylcholine receptor. Receptors Channels, 6(6),415-24 

47. Kim HK, Kaang BK, 1998: Truncated green fluorescent protein mutants and their expression in Aplysia neurons. Brain Res Bull, 47(1),35-41  

48. Bailey CH, Kaang BK, Chen M, Lim CS, Casadio A, Kandel ER, 1997: Mutation in the phosphorylation sites of MAP kinase blocks learning-related internalization of apCAM in Aplysia sensory neurons. Neuron, 18(6),913-24  

49. Lim CS, Chung DY, Kaang BK, 1997: Partial anatomical and physiological characterization and dissociated cell culture of the nervous system of the marine mollusc Aplysia kurodai. Mol Cells, 7(3),399-407  

50. Kaang BK, 1996: Parameters influencing ectopic gene expression in Aplysia neurons. Neurosci Lett, 221(1),29-32  

51. Kaang BK, 1996: Neuronal expression of reporter genes in the intact nervous system of Aplysia. Mol Cells, 6,285

52. Zhao B, Rassendren F, Kaang BK, Furukawa Y, Kubo T, Kandel ER, 1994: A new class of noninactivating K+ channels from aplysia capable of contributing to the resting potential and firing patterns of neurons. Neuron, 13(5),1205-13  

53. Bacskai BJ, Hochner B, Mahaut-Smith M, Adams SR, Kaang BK, Kandel ER, Tsien RY, 1993: Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science, 260(5105),222-6  

54. Kaang BK, Kandel ER, Grant SG, 1993: Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron, 10(3),427-35  

55. Adams SR, Bacskai BJ, Hochner B, Kaang BK, Kandel ER, Mahaut-Smith M, Tsien RY, 1993: Confocal imaging of cAMP signals in Aplysia neurons. Jpn J Physiol, 43(Suppl1),S91-3