1. Kwak JH, Kim S, Yu NK, Seo H, Choi JE, Kim J, Choi DI, Kim MW, Kwak C, Lee K, Kaang BK, 2021: Loss of the neuronal genome organizer and transcription factor CTCF induces neuronal death and reactive gliosis in the anterior cingulate cortex. Genes, Brain, and Behavior. 2021 Feb; e12701. doi: 10.1111/gbb.12701

    2. Choi DI, Kim M, Kim S, Yu NK, Kwak C, Seo H, Lee K & Kaang BK, 2021: Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency. Mol Brain 14, 1 (2021). doi: 10.1186/s13041-020-00716-z

    3. Park P, Kang H, Georgiou J, Zhuo M, Kaang BK, Collingridge G.L, 2021: Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses. Mol Brain. 2021 Jan; doi: 10.1186/s13041-021-00737-2
    4. Park P, Georgiou J, Sanderson TM, Ko KH, Kang H, Kim JI, Bradley CA, Bortolotto ZA, Zhuo M, Kaang BK, Collingridge GL, 2021:  PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus. Nat Commun. 2021 Jan; doi: 10.1038/s41467-020-20523-3.

    5. Han DH, Park P, Choi DI, Bliss TVP, Kaang BK, 2021: The essence of the engram: Cellular or synaptic? Semin Cell Dev Biol. 2021 Jun; doi: 10.1016/j.semcdb.2021.05.033.

    6. Lim CS, Kim MJ, Choi JE, Islam MA, Lee YK, Xiong Y, Shim KW, Yang JE, Lee RU, Lee J, Park P, Kwak JH, Seo H, Kim CH, Lee JH, Lee YS, Hwang SK, Lee K, Lee JA, Kaang BK, 2021: Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice. Mol Psychiatry.2021 Jun. doi: 10.1038/s41380-021-01216-9.

    7. Choi DI, Kim J, Lee H, Kim JI, Sung Y, Choi JE, Venkat SJ, Park P, Jung H, Kaang BK, 2021: Synaptic correlates of associative fear memory in the lateral amygdala. Neuron 2021 Sep; doi: 10.1016/j.neuron.2021.07.003.

    8. Han DH, Hong I, Choi JE, Park P, Baek JY, Park HJ, Ide S , Mishina M , Ikeda K, Kaang BK, 2021: Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice. Mol Brain. 2021 Dec. doi: 10.1186/s13041-021-00883-7


    1. Lee H, Lim CS, Park P, Choi JE, Kwak JH, Lee J, Kaang BK, McHugh T.J, Lee K, 2020: Perseverative stereotypic behavior of Epac2 KO mice in a reward-based decision making task. Neuroscience Research. 2020 Dec; Volume 161, 2020, Pages 8-17, doi: 10.1016/j.neures.2020.08.010

    2. Lee J, Yoon KJ, Park P, Lee C, Kim MJ, Han DH, Kim J, Kim S, Lee HR, Lee Y, Jang EH, Ko HG, Kong YY, Kaang BK, 2020: Neur1 and Neur2 are required for hippocampus-dependent spatial memory and synaptic plasticity. Hippocampus. 2020 Nov; Volume 30(11), 2020, Pages 1158-1166, doi: 10.1002/hipo.23247

    3. Choi DI, Kim J, Kim J, Lee H, Choi JE, Park P, Jung H, Kaang BK, 2020: Synaptic correlates of associative fear memory in the lateral amygdala. BioRxiv. 2020 Sep; doi:

    4. Lee J, Lee HR, Kim JI, Baek J, Jang EH, Lee J, Kim M, Lee RU, Kim S, Park P, Kaang BK, 2020: Transient cAMP elevation during systems consolidation enhances remote contextual fear memory. Neurobiol Learn Mem. 2020 Mar; doi: 10.1016/j.nlm.2020.107171.
    5. Ko HG, Park DI, Lee JH, Turck CW, Kaang BK, 2020: Proteomic analysis of synaptic protein turnover in the anterior cingulate cortex after nerve injury. Mol Brain. 2020 Feb; doi: 10.1186/s13041-020-0564-y.

    6. Lee YS, Yu NK, Chun J, Yang JE, Lim CS, Kim H, Park G, Lee JA, Lee K, Kaang BK, Lee JH, 2020: Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder. Mol Brain 2020 Apr; doi: 10.1186/s13041-020-00595-4.

    7. Lee YK, Lee SK, Choi S, Huh YH, Kwak JH, Lee YS, Jang DJ, Lee JH, Lee K, Kaang BK, Lim CS, Lee JA, 2020: Autophagy pathway upregulation in a human iPSC-derived neuronal model of Cohen syndrome with VPS13B missense mutations. Mol Brain 2020 May; doi: 10.1186/s13041-020-00611-7.

    8. Lee YK, Hwang SK, Lee SK, Yang JE, Kwak JH, Seo H, Ahn H, Lee YS, Kim J, Lim CS, Kaang BK, Lee JH, Lee JA, Lee K, 2020: Cohen Syndrome Patient iPSC-Derived Neurospheres and Forebrain-Like Glutamatergic Neurons Reveal Reduced Proliferation of Neural Progenitor Cells and Altered Expression of Synapse Genes. J Clin Med 2020 Jun; doi: 10.3390/jcm9061886.


    1. Choi DI, Kim J, Kaang BK, 2019: Tracing the Physical Evidence of Memory. Journal of Cognitive Science. 2019 Dec  24; 20(4), 433-448.  doi : 10.17791/jcs.2019.20.4.433
    2. Kim MJ, Lee RU, Oh J, Choi JE, Kim HP, Lee KM, Hwang SK, Lee JH, Lee JA, Kaang BK, Lim CS, Lee YS, 2019: Spatial Learning and Motor Deficits in Vacuolar Protein Sorting-associated Protein 13b (Vps13b) Mutant Mouse. Exp Neurobiol. 2019 Aug; 28(4): 485–494. doi: 10.5607/en.2019.28.4.485
    3. Park H, Kaang BK, 2019: Balanced actions of protein synthesis and degradation in memory formation. Learn. Mem. 2019 Jul; 26: 299-306. doi: 10.1101/lm.048785.118
    4. Oh J, Lee C, 2019: Imaging and analysis of genetically encoded calcium indicators linking neural circuits and behaviors. KJPP. 2019 Jun; 23(4): 237-249. doi: https://doi.org/10.4196/kjpp.2019.23.4.237
    5. Ye S, Kim JI, Kim J, Kaang BK, 2019: Overexpression of activated CaMKII in the CA1 hippocampus impairs context discrimination, but not contextual conditioning. Mol Brain. 2019 Apr 5;12(1):32. doi: 10.1186/s13041-019-0454-3.
    6. Park P, Sanderson TM, Bortolotto ZA, Georgiou J, Zhuo M, Kaang BK, Collingridge GL, 2019: Differential sensitivity of three forms of hippocampal synaptic potentiation to depotentiation. Mol Brain. 2019 Apr 3;12(1):30. doi: 10.1186/s13041-019-0451-6.
    7. Park P, Kang H, Sanderson TM, Bortolotto ZA, Georgiou J, Zhuo M, Kaang BK, Collingridge GL, 2019: On the Role of Calcium-Permeable AMPARs in Long-Term Potentiation and Synaptic Tagging in the Rodent Hippocampus. Front Synaptic Neurosci. 2019 Mar 14;11:4. doi: 10.3389/fnsyn.2019.00004. eCollection 2019.
    8. Ryu HH, Kim T, Kim JW, Kang M, Park P, Kim YG, Kim H, Ha J, Choi JE, Lee J, Lim CS, Kim CH, Kim SJ, Silva AJ, Kaang BK, Lee YS, 2019: Excitatory neuron-specific SHP2-ERK signaling network regulates synaptic plasticity and memory. Sci Signal. 2019 Mar 5;12(571). pii: 12/571/eaau5755. doi: 10.1126/scisignal.aau5755.


  1. Bear MF, Cooke SF, Giese KP, Kaang BK, Kennedy MB, Kim JI, Morris RGM, Park P, 2018: In memoriam: John Lisman - commentaries on CaMKII as a memory molecule. Mol Brain. 2018 Dec 28;11(1):76. doi: 10.1186/s13041-018-0419-y.
  2. Sanderson TM, Bradley CA, Georgiou J, Hong YH, Ng AN, Lee Y, Kim HD, Kim D, Amici M, Son GH, Zhuo M, Kim K, Kaang BK, Kim SJ, Collingridge GL, 2018: The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression. Cell Rep. 2018 Dec 26;25(13):3631-3646.e3. doi: 10.1016/j.celrep.2018.12.010.
  3. Park P, Kang H, Sanderson TM, Bortolotto ZA, Georgiou J, Zhuo M, Kaang BK, Collingridge GL, 2018: The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus. Front Synaptic Neurosci. 2018 Nov 22;10:42. doi: 10.3389/fnsyn.2018.00042. eCollection 2018.
  4. Chung C, Ha S, Kang H, Lee J, Um SM, Yan H, Yoo YE, Yoo T, Jung H, Lee D, Lee E, Lee S, Kim J, Kim R, Kwon Y, Kim W, Kim H, Duffney L, Kim D, Mah W, Won H, Mo S, Kim JY, Lim CS, Kaang BK, Boeckers TM, Chung Y, Kim H, Jiang YH, Kim E, 2018: Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2(-/-) Mice. Biol Psychiatry. 2019 Apr 1;85(7):534-543. doi: 10.1016/j.biopsych.2018.09.025. Epub 2018 Oct 9.
  5. Choi JE, Kim S, Lee J, Kim K, Kaang BK, 2018: Circadian Regulation by REV-ERBalpha Mediates Hippocampal E-LTP in a Time-dependent Manner. Exp Neurobiol. 2018 Oct;27(5):344-349. doi: 10.5607/en.2018.27.5.344. Epub 2018 Oct 31.
  6. Kim H, Kim HS, Kaang BK, 2018: Elevated contextual fear memory by SIRT6 depletion in excitatory neurons of mouse forebrain. Mol Brain. 2018 Sep 6;11(1):49. doi: 10.1186/s13041-018-0391-6.
  7. Oh JY, Lim CS, Yoo KS, Park H, Park YS, Kim EG, Lee YS, Kaang BK, Kim HK, 2018: Adenomatous polyposis coli-stimulated GEF 1 (Asef1) is a negative regulator of excitatory synaptic function. J Neurochem. 2018 Dec;147(5):595-608. doi: 10.1111/jnc.14570. Epub 2018 Nov 20.
  8. Kim JI, Choi DI, Kaang BK, 2018: Strengthened connections between engrams encode specific memories. BMB Rep. 2018 Aug;51(8):369-370.
  9. Wegener S, Buschler A, Stempel AV, Kang SJ, Lim CS, Kaang BK, Shoichet SA, Manahan-Vaughan D, Schmitz D, 2018: Defective Synapse Maturation and Enhanced Synaptic Plasticity in Shank2 Deltaex7(-/-) Mice. eNeuro. 2018 Jul 10;5(3). pii: eN-NWR-0398-17. doi: 10.1523/ENEURO.0398-17.2018. eCollection 2018 May-Jun.
  10. Ko HG, Ye S, Han DH, Park P, Lim CS, Lee K, Zhuo M, Kaang BK, 2018: Transcription-independent expression of PKMzeta in the anterior cingulate cortex contributes to chronically maintained neuropathic pain. Mol Pain. 2018 Jan-Dec;14:1744806918783943. doi: 10.1177/1744806918783943.
  11. Kim S, Yu NK, Shim KW, Kim JI, Kim H, Han DH, Choi JE, Lee SW, Choi DI, Kim MW, Lee DS, Lee K, Galjart N, Lee YS, Lee JH, Kaang BK, 2018: Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF). J Neurosci. 2018 May 30;38(22):5042-5052. doi: 10.1523/JNEUROSCI.2738-17.2018. Epub 2018 Apr 30.
  12. Choi JH, Sim SE, Kim JI, Choi DI, Oh J, Ye S, Lee J, Kim T, Ko HG, Lim CS, Kaang BK, 2018: Interregional synaptic maps among engram cells underlie memory formation. Science. 2018 Apr 27;360(6387):430-435. doi: 10.1126/science.aas9204.
  13. Lim CS, Kim JI, Kwak C, Lee J, Jang EH, Oh J, Kaang BK, 2018: beta-Adrenergic signaling is required for the induction of a labile state during memory reconsolidation. Brain Res Bull. 2018 Jul;141:50-57. doi: 10.1016/j.brainresbull.2018.04.011. Epub 2018 Apr 20.
  14. Park S, Kang W, Kwon YD, Shim J, Kim S, Kaang BK, Hohng S, 2018: Superresolution fluorescence microscopy for 3D reconstruction of thick samples. Mol Brain. 2018 Mar 15;11(1):17. doi: 10.1186/s13041-018-0361-z.
  15. Ko HG, Choi JH, Park DI, Kang SJ, Lim CS, Sim SE, Shim J, Kim JI, Kim S, Choi TH, Ye S, Lee J, Park P, Kim S, Do J, Park J, Islam MA, Kim HJ, Turck CW, Collingridge GL, Zhuo M, Kaang BK, 2018: Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury. Cell Rep. 2018 Jan 16;22(3):748-759. doi: 10.1016/j.celrep.2017.12.059.


  1. Yu NK, Uhm H, Shim J, Choi JH, Bae S, Sacktor TC, Hohng S, Kaang BK., 2017: Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors.,Mol Brain. 2017 Nov 29;10(1):56.
  2. Kim H, Kim S, Choi JE, Han D, Koh SM, Kim HS, Kaang BK., 2017: Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory.,Neurochem Res. 2017 Oct 26;[Epub ahead of print].
  3. Kang SJ, Kim S, Lee J, Kwak C, Lee K, Zhuo M, Kaang BK., 2017: Inhibition of anterior cingulate cortex excitatory neuronal activity induces conditioned place preference in a mouse model of chronic inflammatory pain.,Korean J Physiol Pharmacol. 2017 Aug 22;21(5):487-493.
  4. Lim CS, Nam HJ, Lee J, Kim D, Choi JE, Kang SJ, Kim S, Kim H, Kwak C, Shim KW, Kim S, Ko HG, Lee RU, Jang EH, Yoo J, Shim J, Islam MA, Lee YS, Lee JH, Baek SH, Kaang BK., 2017: PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory.,Sci Rep. 2017 Jul 7;7(1):4912.
  5. Kim SJ, Jeong MJ, Jo HJ, Jung JH, Kaang BK, Choi YB, Kim JH., 2017: Identification of postsynaptic phosphatidylinositol-4,5-bisphosphate (PIP2) roles for synaptic plasticity using chemically induced dimerization.,Sci Rep. 2017 Jun 13;7(1):3351.
  6. Nah J, Yoo SM, Jung S, Jeong EI, Park M, Kaang BK, Jung YK., 2017: Phosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress.,Cell Death Dis. 2017 May 25;8(5):e2822.
  7. Lim CS, Kang X, Mirabella V, Zhang H, Bu Q, Araki Y, Hoang ET, Wang S, Shen Y, Choi S, Kaang BK, Chang Q, Pang ZP, Huganir RL, Zhu JJ., 2017: Erratum: BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.,Genes Dev. 2017 Apr 15;31(8):846.
  8. Lim CS, Kang X, Mirabella V, Zhang H, Bu Q, Araki Y, Hoang ET, Wang S, Shen Y, Choi S, Kaang BK, Chang Q, Pang ZP, Huganir RL, Zhu JJ., 2017: BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.,Genes Dev. 2017 Mar 15;31(6):537-552.
  9. Yoon SY, Kwon SG, Kim YH, Yeo JH, Ko HG, Roh DH, Kaang BK, Beitz AJ, Lee JH, Oh SB., 2017: A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.,Mol Pain. 2017 Jan;13:1744806916688902.
  10. Lee YK, Jun YW, Choi HE, Huh YH, Kaang BK, Jang DJ, Lee JA., 2017: Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.,EMBO J. 2017 Mar 20;36(8):1100-1116.
  11. Yoo M, Choi KY, Kim J, Kim M, Shim J, Choi JH, Cho HY, Oh JP, Kim HS, Kaang BK, Han JH., 2017: BAF53b, a Neuron-Specific Nucleosome Remodeling Factor, Is Induced after Learning and Facilitates Long-Term Memory Consolidation.,J Neurosci. 2017 Mar 7;37(13):3686-3697.
  12. Jun MH, Ryu HH, Jun YW, Liu T, Li Y, Lim CS, Lee YS, Kaang BK, Jang DJ, Lee JA., 2017: Sequestration of PRMT1 and Nd1-L mRNA into ALS-linked FUS mutant R521C-positive aggregates contributes to neurite degeneration upon oxidative stress.,Sci Rep. 2017 Jan 17;7:40474.
  13. Kim S, Kaang BK., 2017: Epigenetic regulation and chromatin remodeling in learning and memory.,Exp Mol Med. 2017 Jan 13;49(1):e281. review
  14. Lim CS, Kim H, Yu NK, Kang SJ, Kim T, Ko HG, Lee J, Yang JE, Ryu HH, Park T, Gim J, Nam HJ, Baek SH, Wegener S, Schmitz D, Boeckers TM, Lee MG, Kim E, Lee JH, Lee YS, Kaang BK., 2017: Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice.,Neuropharmacology. 2017 Jan;112(Pt A):104-112.


  1. Lee J, Ko HG, Kim K, Kaang BK., 2016: Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice.,Exp Neurobiol.2016 Dec;25(6):342-346. 
  2. Kang SJ, Kaang BK., 2016: Metabotropic glutamate receptor dependent long-term depression in the cortex.,Korean J Physiol Pharmacol.2016 Nov;20(6):557-564. review 
  3. Jun YW, Lee SH, Shim J, Lee JA, Lim CS, Kaang BK, Jang DJ., 2016: Dual roles of the N-terminal coiled-coil domain of an Aplysia sec7 protein: homodimer formation and nuclear export.,J Neurochem.2016 Oct 27;[Epub ahead of print]. review 
  4. Lee SH, Shim J, Cheong YH, Choi SL, Jun YW, Lee SH, Chae YS, Han JH, Lee YS, Lee JA, Lim CS, Si K, Kassabov S, Antonov I, Kandel ER, Kaang BK, Jang DJ., 2016: ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation.,Mol Brain.2016 Oct 22;9(1):91. 
  5. Lim CS, Kim H, Yu NK, Kang SJ, Kim T, Ko HG, Lee J, Yang JE, Ryu HH, Park T, Gim J, Nam HJ, Baek SH, Wegener S, Schmitz D, Boeckers TM, Lee MG, Kim E, Lee JH, Lee YS, Kaang BK., 2016: Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice.,2016 Aug 17;[Epub ahead of print]. 
  6. Sim SE, Lim CS, Kim JI, Seo D, Chun H, Yu NK, Lee J, Kang SJ, Ko HG, Choi JH, Kim T, Jang EH, Han J, Bak MS, Park JE, Jang DJ, Baek D, Lee YS, Kaang BK., 2016: The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and Memory.,J Neurosci. 2016 Aug 17;36(33):8641-52. 
  7. Cho J, Yu NK, Kim VN, Kaang BK., 2016: Response to Comment on "Multiple repressive mechanisms in the hippocampus during memory formation".,Science. 2016 Jul 29;353(6298):453. 
  8. Jang DJ, Jun YW, Shim J, Sim SE, Lee JA, Lim CS, Kaang BK., 2016: Activation of Aplysia ARF6 induces neurite outgrowth and is sequestered by the overexpression of the PH domain of Aplysia Sec7 proteins.,Neurobiol Learn Mem. 2016 Jun 21;[Epub ahead of print]. 
  9. Ko HG, Kim JI, Sim SE, Kim T, Yoo J, Choi SL, Baek SH, Yu WJ, Yoon JB, Sacktor TC, Kaang BK., 2016: The role of nuclear PKMζ in memory maintenance.,Neurobiol Learn Mem. 2016 Jun 14;[Epub ahead of print]. 
  10. Bliss TV, Collingridge GL, Kaang BK, Zhuo M., 2016: Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain.,Nat Rev Neurosci. 2016 Jun 16;17(8):485-96. 
  11. Hwang SK, Lee JH, Yang JE, Lim CS, Lee JA, Lee YS, Lee K, Kaang BK., 2016: Everolimus improves neuropsychiatric symptoms in a patient with tuberous sclerosis carrying a novel TSC2 mutation.,Mol Brain. 2016 May 23;9(1):56. 
  12. Ko HG, Oh SB, Zhuo M, Kaang BK., 2016: Reduced acute nociception and chronic pain in Shank2-/- mice.,Mol Pain. 2016 May 4;12. 
  13. Kim JI, Cho HY, Han JH, Kaang BK., 2016: Which Neurons Will Be the Engram - Activated Neurons and/or More Excitable Neurons?,Exp Neurobiol. 2016 Apr 14;25(2):55-63. review 
  14. Yu NK, Kim HF, Shim J, Kim S, Kim DW, Kwak C, Sim SE, Choi JH, Ahn S, Yoo J, Choi SL, Jang DJ, Lim CS, Lee YS, Kang C, Choi SY, Kaang BK., 2016: A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission.,Sci Rep. 2016 Mar 10;6:22892. 
  15. Jun YW, Park H, Lee YK, Kaang BK, Lee JA, Jang DJ., 2016: D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane.,FEBS Lett. 2016 Mar 28;590(7):954-61. 
  16. Yu NK, Kaang BK., 2016: Gene Repressive Mechanisms in the Mouse Brain Involved in Memory Formation.,BMB Rep. 2016 Mar 7;[Epub ahead of print]. 
  17. Kim S, Kim T, Lee HR, Jang EH, Ryu HH, Kang M, Rah SY, Yoo J, Lee B, Kim JI, Lim CS, Kim SJ, Kim UH, Lee YS, Kaang BK., 2016: Impaired learning and memory in CD38 null mutant mice.,Mol Brain. 2016 Feb 9;9(1):16
  18. Kim H, Lim CS, Kaang BK., 2016: Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder.,Behav Brain Funct. 2016 Jan 20;12(1):3 
  19. Park P, Sanderson TM, Amici M, Choi SL, Bortolotto ZA, Zhuo M, Kaang BK, Collingridge GL., 2016: Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.,J Neurosci. 2016 Jan 13;36(2):622-31 


  1. Lee CH, Kaang BK, Lee YD., 2015: Structure and Function of the Reproductive System of Aplysia kurodai.,Dev Reprod. 2015 Dec;19(4):197-207. 
  2. Kwak C, Lim CS, Kaang BK., 2015: Assessments of cognitive abilities in a mouse model of Parkinson's disease with a touch screen test.,Behav Brain Res. 2015 Dec 14.;301:63-71. 
  3. Jun MH, Han JH, Lee YK, Jang DJ, Kaang BK, Lee JA., 2015: TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.,Mol Brain. 2015 Dec 10;8:85
  4. Kang SJ, Kwak C, Lee J, Sim SE, Shim J, Choi T, Collingridge GL, Zhuo M, Kaang BK., 2015: Bidirectional modulation of hyperalgesia via the specific control of excitatory and inhibitory neuronal activity in the ACC.,Mol Brain. 2015 Dec 2;8(1):81 
  5. Jang S, Oh D, Lee Y, Hosy E, Shin H, van Riesen C, Whitcomb D, Warburton JM, Jo J, Kim D, Kim SG, Um SM, Kwon SK, Kim MH, Roh JD, Woo J, Jun H, Lee D, Mah W, Kim H, Kaang BK, Cho K, Rhee JS, Choquet D, Kim E., 2015: Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity.,Nat Neurosci. 2015 Nov 23.;19(1):84-93. 
  6. Kim S, Kim T, Lee HR, Kong YY, Kaang BK., 2015: Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity.,Korean J Physiol Pharmacol. 2015 Oct 16.;19(6):515-22. 
  7. Cho J, Yu NK, Choi JH, Sim SE, Kang SJ, Kwak C, Lee SW, Kim JI, Choi DI, Kim VN, Kaang BK., 2015: Multiple repressive mechanisms in the hippocampus during memory formation.,Science. 2015 Oct 2;350(6256):82-7 
  8. Lim CS, Yang JE, Lee YK, Lee K, Lee JA, Kaang BK., 2015: Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients.,Mol Brain. 2015 Sep 30;8(1):57 
  9. Jang DJ, Kim HF, Sim JH, Lim CS, Kaang BK., 2015: Specific Expression of Aplysia Phosphodiesterase 4 in Bag Cells Revealed by in situ Hybridization Analysis.,Exp Neurobiol. 2015 Aug 13.;24(3):246-51. 
  10. Lee YS, Lee JA, Kaang BK., 2015: Regulation of mRNA stability by ARE-binding proteins in synaptic plasticity and memory.,Neurobiol Learn Mem. 2015 Aug 17. pii: S1074-7427(15)00152-5. 
  11. Lee K, Kobayashi Y, Seo H, Kwak JH, Masuda A, Lim CS, Lee HR, Kang SJ, Park P, Sim SE, Kogo N, Kawasaki H, Kaang BK, Itohara S., Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility., Mol Brain. 2015 Jun 24;8:38. 
  12. Shin W, Yu NK, Kaang BK, Rhee K., 2015: The microtubule nucleation activity of centrobin in both the centrosome and cytoplasm., ell Cycle. 2015;14(12):1925-31. 
  13. Kim S, Yu NK, Kaang BK., 2015: CTCF as a multifunctional protein in genome regulation and gene expression., Exp Mol Med. 2015 Jun 5;47:e166. Review. 
  14. Park J, Lim CS, Seo H, Park CA, Zhuo M, Kaang BK, Lee K., 2015: Pain perception in acute model mice of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)., Mol Pain. 2015 May 17;11:28. 
  15. Kwak C, Lim CS, Kaang BK., 2015: Development of a touch-screen-based paradigm for assessing working memory in the mouse., Exp Neurobiol. 2015 Mar;24(1):84-9 
  16. Jun YW, Kim S, Kim KH, Lee JA, Lim CS, Chang I, Suh BC, Kaang BK, Jang DJ., 2015: Analysis of Phosphoinositide-Binding Properties and Subcellular Localization of GFP-Fusion Proteins., Lipids. 2015 Feb 17.
  17. Kim T, Lim CS, Kaang BK., 2015: Cell type-specific gene expression profiling in brain tissue: Comparison among TRAP, LCM and RNA-seq., BMB Rep. 2015 Jan 21. 
  18. Koga K, Descalzi G, Chen T, Ko HG, Lu J, Li S, Son J, Kim T, Kwak C, Huganir RL, Zhao MG, Kaang BK, Collingridge GL, Zhuo M., 2015: Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain., Neuron. 2015 Jan 21;85(2):377-89. 


  1. Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS., 2014: Differential Distribution of PI3K Isoforms in Spinal Cord and Dorsal Root Ganglia: Potential Roles in Acute Inflammatory Pain., Pain. 2014 Mar 11. 
  2. Choi JH, Yu NK, Baek GC, Bakes J, Seo D, Nam HJ, Baek SH, Lim CS, Lee YS, Kaang BK., 2014: Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons., Mol Brain.2014 Mar 11 
  3. Lee YS, Ehninger D, Zhou M, Oh JY, Kang M, Kwak C, Ryu HH, Butz D, Araki T, Cai Y, Balaji J, Sano Y, Nam CI, Kim HK, Kaang BK, Burger C, Neel BG, Silva AJ., 2014: Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome., Nat Neurosci. 2014 Dec;17(12):1736-43. 
  4. Choi JH, Park P, Baek GC, Sim SE, Kang S, Lee Y, Ahn SH, Lim CS, Lee YS, Collingridge GL, Kaang BK. 2014: Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning., Mol Brain. 2014 Nov 6;7(1):78. 
  5. Kim KH, Jun YW, Park Y, Lee JA, Suh BC, Lim CS, Lee YS, Kaang BK, Jang DJ. 2014: Intracellular membrane association of the Aplysia cAMP phosphodiesterase long and short forms via different targeting mechanisms. J Biol Chem. 2014 Sep 12;289(37):25797-811. 
  6. Sim SE, Bakes J, Kaang BK. 2014: Neuronal activity-dependent regulation of MicroRNAs.Mol Cells. 2014 Jul;37(7):511-7. 


  1. Yoo J, Bakes J, Bradley C, Collingridge GL, Kaang BK., 2013: Shank mutant mice as an animal model of autism., Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130143. 
  2. Park P, Volianskis A, Sanderson TM, Bortolotto ZA, Jane DE, Zhuo M, Kaang BK, Collingridge GL., 2013: NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation., Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130131. 
  3. Kang SJ, Liu MG, Shi TY, Zhao MG, Kaang BK, Zhuo M., 2013: N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice., Mol Pain. 2013 Nov 14;9:58. 
  4. Liu MG, Koga K, Guo YY, Kang SJ, Collingridge GL, Kaang BK, Zhao MG, Zhuo M., 2013: Long-term depression of synaptic transmission in the adult mouse insular cortex in vitro., Eur J Neurosci. 2013 Aug 11. 
  5. Jang EH, Ahn SH, Lee YS, Lee HR, Kaang BK., 2013: Effect of Food Deprivation on a Delayed Nonmatch-to-place T-maze Task., Exp Neurobiol. 2013 Jun;22(2):124-7.
  6. Qiu S, Chen T, Koga K, Guo YY, Xu H, Song Q, Wang JJ, Descalzi G, Kaang BK, Luo JH, Zhuo M, Zhao MG., 2013: An Increase in Synaptic NMDA Receptors in the Insular Cortex Contributes to Neuropathic Pain., Sci Signal. 2013 May 14;6(275):ra34.
  7. Seo-Hee Ahn , Eun-Hae Jang , Jun-Hyeok Choi , Hye-Ryeon Lee , Joseph Bakes , Young-Yun Kong & Bong-Kiun Kaang., 2013: Basal anxiety during an open field test is correlated with individual differences in contextually conditioned fear in mice., Animal Cells and Systems, 2013 May 10;17(3): 154-159,
  8. Park AY, Chae YS, Lee SH, Kaang BK, Lee S., 2013: Presynaptic structure of aplysia single live neuron by atomic force and confocal laser scanning microscope., J Phys Chem B. 2013 May 2;117(17):4779-88.
  9. Liu MG, Kang SJ, Shi TY, Koga K, Zhang MM, Collingridge GL, Kaang BK, Zhuo M., 2013: Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multi-electrode array recordings., J Neurophysiol. 2013 May 1.
  10. Hong I, Kim J, Kim J, Lee S, Ko HG, Nader K, Kaang BK, Tsien RW, Choi S., 2013: AMPA receptor exchange underlies transient memory destabilization on retrieval., Proc Natl Acad Sci U S A. 2013 Apr 29.
  11. Lee SH,Shim J and Kaang BK., 2013: The role of cell adhesion molecules (CAMs) in defining synapse-specific function and plasticity., Anim Cells Syst. 12 Mar 2013;17(1) : 1-6. 
  12. Sim SE, Lee HR, Kim JI, Choi SL, Bakes J, Jang DJ, Lee K, Han K, Kim E, Kaang BK., 2013: Elevated RalA activity in the hippocampus of PI3Kγ knock-out mice lacking NMDAR-dependent long-term depression. BMB Rep. 2013 Feb;46(2):103-6.


  1. Do J, Kim JI, Bakes J, Lee K, Kaang BK. 2012: Functional roles of neurotransmitters and neuromodulators in the dorsal striatum. Learn Mem. 2012 Dec 17;20(1):21-8.
  2. Lee SH, Shim J, Choi SL, Lee N, Lee CH, Bailey CH, Kandel ER, Jang DJ, Kaang BK., 2012: Learning-related synaptic growth mediated by internalization of Aplysia cell adhesion molecule is controlled by membrane phosphatidylinositol 4,5-bisphosphate synthetic pathway. J Neurosci. 2012 Nov 14;32(46):16296-305.
  3. Kwak C, Choi JH, Bakes JT, Lee K, Kaang BK., 2012: Effect of intensity of unconditional stimulus on reconsolidation of contextual fear memory. Korean J Physiol Pharmacol. 2012 Oct;16(5):293-6.
  4. Yoon KJ, Lee HR, Jo YS, An K, Jung SY, Jeong MW, Kwon SK, Kim NS, Jeong HW, Ahn SH, Kim KT, Lee K, Kim E, Kim JH, Choi JS, Kaang BK, Kong YY., 2012: Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Mol Brain. 2012 Oct 30;5:40.
  5. Lee YS, Choi SL, Jun H, Yim SJ, Lee JA, Kim HF, Lee SH, Shim J, Lee K, Jang DJ, Kaang BK., 2012: AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia. Proc Natl Acad Sci U S A. 2012 Sep 4. [Epub ahead of print]
  6. Kang SJ, Liu MG, Chen T, Ko HG, Baek GC, Lee HR, Lee K, Collingridge GL, Kaang BK, Zhuo M., 2012: Plasticity of Metabotropic Glutamate Receptor-Dependent Long-Term Depression in the Anterior Cingulate Cortex after Amputation. J Neurosci. 2012 Aug 15;32(33):11318-11329.
  7. Lee SH, Kwak C, Shim J, Kim JE, Choi SL, Kim HF, Jang DJ, Lee JA, Lee K, Lee CH, Lee YD, Miniaci MC, Bailey CH, Kandel ER, Kaang BK., 2012: A cellular model of memory reconsolidation involves reactivation-induced destabilization and restabilization at the sensorimotor synapse in Aplysia. Proc Natl Acad Sci U S A.2012 Aug 28;109(35):14200-5. Epub 2012 Aug 14.
  8. Koga K, Sim SE, Chen T, Wu LJ, Kaang BK, Zhuo M., 2012: Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex. J Neurophysiol. 2012 Jul 11.
  9. Won H, Lee HR, Gee HY, Mah W, Kim JI, Lee J, Ha S, Chung C, Jung ES, Cho YS, Park SG, Lee JS, Lee K, Kim D, Bae YC, Kaang BK, Lee MG, Kim E., 2012: Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature. 2012 Jun 13;486(7402):261-5. doi: 10.1038/nature11208.
  10. Bradley CA, Peineau S, Taghibiglou C, Nicolas CS, Whitcomb DJ, Bortolotto ZA, Kaang BK, Cho K, Wang YT, Collingridge GL.,2012: A pivotal role of GSK-3 in synaptic plasticity. Front Mol Neurosci. 2012;5:13. Epub 2012 Feb 15.
  11. Nicolas CS, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, Collett VJ, Hildebrandt L, Seaton G, Choi SL, Sim SE, Bradley C, Lee K, Zhuo M, Kaang BK, Gressens P, Dournaud P, Fitzjohn SM, Bortolotto ZA, Cho K, Collingridge GL., 2012: The Jak/STAT pathway is involved in synaptic plasticity. Neuron. 2012 Jan 26;73(2):374-90.
  12. Hyun NG, Hyun KH, Lee K, Kaang BK., 2012: Temperature Dependence of Action Potential Parameters in Aplysia Neurons. Neurosignals. 2012 Jan 17.
  13. Kaang BK, Choi JH., 2012: Synaptic protein degradation in memory reorganization. Adv Exp Med Biol.2012;970:221-40. Review.


  1. Lee B, Descalzi G, Baek J, Kim JI, Lee HR, Lee K, Kaang BK, Zhuo M., 2011: Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ). Mol Pain. 2011 Dec 14;7:96.
  2. Sim SE, Park SW, Choi SL, Yu NK, Ko HG, Jang DJ, Lee K, Kaang BK., 2011: Assessment of the effects of virus-mediated limited Oct4 overexpression on the structure of the hippocampus and behavior in mice. BMB Rep. 2011 Dec;44(12):793-8.
  3. Hyun NG, Hyun KH, Hyun KB, Han JH, Lee K, Kaang BK., 2012: A Computational Model of the Temperature-dependent Changes in Firing Patterns in Aplysia Neurons Korean J Physiol Pharmacol. 2011 Dec;15(6):371-82. Epub 2011 Dec 27.
  4. Ye-Hwang Cheong, Mi-Kyung Kim, Moon-Ho Son and Bong-Kiun Kaang, 2011: Glucose exposure pattern determines glucagon-like peptide 1 receptor expression and signaling through endoplasmic reticulum stress in rat insulinoma cells. Biochemical and Biophysical Research Communications
  5. Jae-Ick Kim, Hye-Ryeon Lee, Su-eon Sim, Jinhee Baek, Nam-Kyung Yu, Jun-Hyeok Choi, Hyoung-Gon Ko, Yong-Seok Lee, Soo-Won Park, Chuljung Kwak, Sung-Ji Ahn, So Yoen Choi, Hyun Kim Kyoung-Han Kim, Peter H Backx, Clarrisa A Bradley, Eunjoon Kim, Deok-Jin Jang, 2011: PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility. Nature Neuroscience
  6. Jung-Ah Min, Hye-Ryeon Lee, Jae-Ick Kim, Anes Ju, Bong-Kiun Kaang, Dai-Jin Kim, 2011: Impairment of long-term potentiation in the hippocampus of alcohol-treated OLETF rats. Neuroscience Letters
  7. Xiang-Yao Li, Hyoung-Gon Ko, Tao Chen, Graham L. Collingridge, Bong-Kiun Kaang and Min Zhuo, 2011: Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain. Journal of Molecular Medicine
  8. Nam-Kyung Yu, Sung H Baek, Bong-Kiun Kaang, 2011: DNA methylation-mediated control of learning and memory. Molecular Brain 2011, 4:5
  9. Hansen Wang, Hui Xu, Long-Jun Wu, Susan S. Kim, Tao Chen, Kohei Koga, Giannina Descalzi, Bo Gong, Kunjumon I. Vadakkan, Xuehan Zhang, Bong-Kiun Kaang, Min Zhuo, 2011: Identification of an Adenylyl Cyclase Inhibitor for Treating Neuropathic and Inflammatory Pain. Sci Transl Med
  10. Bong-Kiun Kaang, Jun-Hyeok Choi, 2011: Protein degradation during reconsolidation as a mechanism for memory reorganization. Frontiers in Behavioral Neuroscience


  1. Li XY, Ko HG, Chen T, Descalzi G, Koga K, Wang H, Kim SS, Shang Y, Kwak C, Park SW, Shim J, Lee K, Collingridge GL, Kaang BK, Zhuo M, 2010: Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science, 330(6009),1400-4
  2. Deok-Jin Jang, Jin-A Lee, Yeon-Su Chae, Bong-Kiun Kaang, 2010: State-dependent disruption of short-term facilitation due to overexpression of the apPDE4 supershort form in Aplysia. Molecules and Cells
  3. Jang DJ, Park SW, Lee JA, Lee C, Chae YS, Park H, Kim MJ, Choi SL, Lee N, Kim H, Kaang BK, 2010: termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranes. Learn Mem, 17(9),469-79
  4. Choi SL, Lee YS, Rim YS, Kim TH, Moroz LL, Kandel ER, Bhak J, Kaang BK, 2010: Differential Evolutionary Rates of Neuronal Transcriptome in Aplysia kurodai and Aplysia californica as a Tool for Gene Mining. J Neurogenet, 24(2),75-82
  5. Lee HR, Kaang BK, 2010: A novel analytic measure for the water maze utilizing the concept of entropy. Front Neurosci, 4,1
  6. Park JW, Park AY, Lee S, Yu NK, Lee SH, Kaang BK, 2010: Detection of TrkB Receptors Distributed in Cultured Hippocampal Neurons through Bioconjugation between Highly Luminescent (Quantum Dot-Neutravidin) and (Biotinylated Anti-TrkB Antibody) on Neurons by Combined Atomic Force Microscope and Confocal Laser Sca. Bioconjug Chem, 21(4),597-603
  7. Park SW, Ko HG, Lee N, Lee HR, Rim YS, Kim H, Lee K, Kaang BK, 2010: Aged wild-type littermates and APPswe+PS1/ΔE9 mice present similar deficits in associative learning and spatial memory independent of amyloid load. Genes & Genomics, 32(1),63-70
  8. Chae YS, Lee SH, Cheang YH, Lee N, Rim YS, Jang DJ, Kaang BK, 2010: Neuronal RNA granule contains ApCPEB1, a novel Aplysia CPEB, in Aplysia sensory neuron. Exp Mol Med, 42(1),30-7
  9. Choi JH, Kim JE, Kaang BK, 2010: Protein synthesis and degradation are required for the incorporation of modified information into the pre-existing object-location memory. Mol Brain, 3,1


  1. Kwak C, Lee SH, Kaang BK, 2009: Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior. Korean J Physiol Pharmacol, 13(5),357-60
  2. Kaang BK, Lee SH, Kim H, 2009: Synaptic Protein Degradation as a Mechanism in Memory Reorganization. Neuroscientist, 15(5),430-5
  3. Lee YS, Choi SL, Lee SH, Kim H, Park H, Lee N, Lee SH, Chae YS, Jang DJ, Kandel ER, Kaang BK, 2009: Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia. Proc Natl Acad Sci U S A, 106(34),14634-9
  4. Lee JS, Jang DJ, Lee N, Ko HG, Kim H, Kim YS, Kim B, Son J, Kim SH, Chung H, Lee MY, Kim WR, Sun W, Zhuo M, Abel T, Kaang BK, Son H, 2009: Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors. J Neurosci, 29(26),8493-505
  5. Lee YS, Kim TH, Choi SL, Lee S, Bhak J, Kaang BK, 2009: Transcriptome and protein domain analyses in Aplysia nervous system with evolutionary implications. Commun Integr Biol, 2(4),321-3
  6. Lee JA, Jang DJ, Kaang BK, 2009: Two major gate-keepers in the self-renewal of neural stem cells: Erk1/2 and PLCgamma1 in FGFR signaling. Mol Brain, 2(1),15
  7. Ko HG, Jang DJ, Son J, Kwak C, Choi JH, Ji YH, Lee YS, Son H, Kaang BK, 2009: Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory. Mol Brain, 2(1),1
  8. Jang DJ, Park SW, Kaang BK, 2009: The role of lipid binding for the targeting of synaptic proteins into synaptic vesicles. BMP Rep, 42(1),1-5
  9. Lee NB, Rim YS, Kaang BK, 2009: Effects of Protease Treatment and Animal Behavior on the Dissociative Culture of Aplysia Neurons. Animal Cells and Systems, 13(3),267-274


  1. Lee YS, Choi SL, Kim TH, Lee JA, Kim HK, Kim H, Jang DJ, Lee JJ, Lee S, Sin GS, Kim CB, Suzuki Y, Sugano S, Kubo T, Moroz LL, Kandel ER, Bhak J, Kaang BK, 2008: Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai. Proc Natl Acad Sci U S A, 105(47),18602-7
  2. Wu LJ, Steenland HW, Kim SS, Isiegas C, Abel T, Kaang BK, Zhuo M, 2008: Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex. Mol Pain, 4,40
  3. Park H, Pack C, Kinjo M, Kaang BK, 2008: In vivo quantitative analysis of PKA subunit interaction and cAMP level by dual color Fluorescence Cross Correlation Spectroscopy. Mol Cells, 26(1),87-92
  4. Isiegas C, McDonough C, Huang T, Havekes R, Fabian S, Wu LJ, Xu H, Zhao MG, Kim JI, Lee YS, Lee HR, Ko HG, Lee N, Choi SL, Lee JS, Son H, Zhuo M, Kaang BK, Abel T, 2008: A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci, 28(24),6220-30
  5. Lee YS, Bailey CH, Kandel ER, Kaang BK, 2008: Transcriptional regulation of long-term memory in the marine snail Aplysia. Mol Brain, 1(1),3
  6. Kim BW, Choi M, Kim YS, Park H, Lee HR, Yun CO, Kim EJ, Choi JS, Kim S, Rhim H, Kaang BK, Son H, 2008: Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin. Cell Signal, 20(4),714-25
  7. Lee SH, Choi JH, Lee N, Lee HR, Kim JI, Yu NK, Choi SL, Lee SH, Kim H, and Kaang BK, 2008: Synaptic protein degradation underlies destabilization of retrieved fear memory. Science, 319(5867),1253-6
  8. Lee HR, Choi JH, Lee N, Kim SH, Kim YC, Kaang BK, 2008: The effect of idesolide on hippocampus-dependent recognition memory. Animal Cells and Systems, 12(1),11


  1. Ko HG, Lee SJ, Son H, Kaang BK, 2007: Null effect of antidepressants on the astrocytes-mediated proliferation of hippocampal progenitor cells in vitro. Mol Pain, 3,16
  2. Lee SH, Lim CS, Park H, Lee JA, Han JH, Kim H, Cheang YH, Lee SH, Lee YS, Ko HG, Jang DH, Kim H, Miniaci MC, Bartsch D, Kim E, Bailey CH, Kandel ER, Kaang BK, 2007: Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia. Cell, 129(4),801-12
  3. Shum FW, Wu LJ, Zhao MG, Toyoda H, Xu H, Ren M, Pinaud R, Ko SW, Lee YS, Kaang BK, Zhuo M, 2007: Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learn Mem, 14(4),304-12
  4. Wang H, Gong B, Vadakkan KI, Toyoda H, Kaang BK, Zhuo M, 2007: Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors. J Bio Chem, 282(2),1507-17
  5. Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, Jia Z, Kaang BK, Kawamata M, Kida S, Klann E, 2006: Recent advances in basic neurosciences and brain disease: from synapses to behavior. Mol Pain, 2,38 
  6. Lee JA, Lee SH, Lee C, Chang DJ, Lee Y, Kim H, Cheang YH, Ko HG, Lee YS, Jun H, Bartsch D, Kandel ER, Kaang BK, 2006: PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation. J Cell Biol, 174(6),827-38 
  7. Yim SJ, Lee YS, Lee JA, Chang DJ, Han JH, Kim H, Park H, Jun H, Kim VN, Kaang BK, 2006: Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation. J Neurochem, 98(2),420-9 
  8. Ko SW, Jia Y, Xu H, Yim SJ, Jang DH, Lee YS, Zhao MG, Toyoda H, Wu LJ, Chatila T, Kaang BK, Zhuo M, 2006: Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. Eur J Neurosci, 23(8),2158-68 
  9. Ko J, Kim S, Chung HS, Kim K, Han K, Kim H, Jun H, Kaang BK, Kim E, 2006: SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses. Neuron, 50(2),233-45 
  10. Kim H, Lee SH, Han JH, Lee JA, Cheang YH, Chang DJ, Lee YS, Kaang BK, 2006: A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in aplysia neurons. Neuron, 49(5),707-18  
  11. Kim JH, Lee JA, Song YM, Park CH, Hwang SJ, Kim YS, Kaang BK, Son H, 2006: Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth. FASEB J, 20(1),109-11 
  12. Jang DH, Han JH, Lee SH, Lee YS, Park H, Lee SH, Kim H, Kaang BK, 2005: Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses. Proc Natl Acad Sci U S A, 102(44),16072-7  
  13. Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M, 2005: Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci, 25(48),11107-16  
  14. Park H, Lee JA, Lee C, Kim MJ, Chang DJ, Kim H, Lee SH, Lee YS, Kaang BK, 2005: An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation. J Neurosci, 25(39),9037-45  
  15. Zhao MG, Toyoda H, Lee YS, Wu LJ, Ko SW, Zhang XH, Jia Y, Shum F, Xu H, Li BM, Kaang BK, Zhuo M, 2005: Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron, 47(6),859-72  
  16. Han JH, Lee C, Cheang Y, Kaang BK, 2005: Suppression of long-term facilitation by Rab3-effector protein interaction. Mol Res Mol Brain Res, 139(1),13-22  
  17. Shum FW, Ko SW, Lee YS, Kaang BK, Zhuo M, 2005: Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV. Mol Pain, 1,22  
  18. Lee Y, Lee Y, Lee J, Bang S, Hyun S, Kang J, Hong ST, Bae E, Kaang BK, Kim J, 2005: Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster. Nat Genet, 37(3),305-10  
  19. Gong Z, Son W, Chung YD, Kim J, Shin DW, McClung CA, Lee Y, Lee HW, Chang DJ, Kaang BK, Cho H, Oh U, Hirsh J, Kernan MJ, Kim C, 2004: Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. J Neurosci, 24(41),9059-66  
  20. Han JH, Lim CS, Lee YS, Kandel ER, Kaang BK, 2004: Role of Aplysia cell adhesion molecules during 5-HT-induced long-term functional and structural changes. Learn Mem, 11(4),421-35  
  21. Chang DJ, Lee SH, Lim CS, Jang DH, Lee CH, Lee YD, Kaang BK, 2004: Thiol oxidation-mediated cell death in Aplysia cultured sensory neurons. Brain Res, 1007(1-2),71-7  
  22. Akalal DB, Bottenstein JE, Lee SH, Han JH, Chang DJ, Kaang BK, Nagle GT, 2003: Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system. Brain Res Mol Brain Res, 117(2),228-36  
  23. Lee Y, Han JH, Lim CS, Chang DJ, Lee YS, Soh H, Park CS, Kaang BK, 2003: Impairment of a parabolic bursting rhythm by the ectopic expression of a small conductance Ca2+-activated K+ channel in Aplysia neuron R15. Neurosci Lett, 349(1),53-7  
  24. Lee Y, Chang DJ, Lee YS, Chang KA, Kim H, Yoon JS, Lee S, Suh YH, Kaang BK, 2003: Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system. J Neurosci Res, 73(2),255-9  
  25. Kim H, Chang DJ, Lee JA, Lee YS, Kaang BK, 2003: Identification of nuclear/nucleolar localization signal in Aplysia learning associated protein of slug with a molecular mass of 18 kDa homologous protein. Neurosci Lett, 343(2),134-8  
  26. Son H, Yu IT, Hwang SJ, Kim JS, Lee SH, Lee YS, Kaang BK, 2003: Lithium enhances long-term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus. J Neurochem, 85(4),872-81  
  27. Lee JA, Lim CS, Lee SH, Kim H, Nukina N, Kaang BK, 2003: Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons. J Neurochem, 85(1),160-9 
  28. Chang DJ, Lim CS, Lee SH, Kaang BK, 2003: Hydrogen peroxide modulates K+ ion currents in cultured Aplysia sensory neurons. Brain Res, 970(1-2),159-68  
  29. Huh M, Han JH, Lim CS, Lee SH, Kim S, Kim E, Kaang BK, 2003: Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons. J Neurochem, 85(1),282-5  
  30. Chang DJ, Lim CS, Lee JA, Kaang BK, 2003: Synaptic facilitation by ectopic octopamine and 5-HT receptors in Aplysia. Brain Res Bull, 60(1-2),73-9  
  31. Lee SH, Han JH, Choi JH, Huh EY, Kwon YK, Kaang BK, 2003: The effect of brain-derived neurotrophic factor on neuritogenesis and synaptic plasticity in Aplysia neurons and the hippocampal cell line HiB5. Mol Cells, 15(2),233-9 
  32. Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E, 2003: The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. J Bio Chem, 278(8),6291-300  
  33. Lee JA, Kim H, Lee YS, Kaang BK, 2003: Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein-2, a repressor of long-term facilitation, in Aplysia kurodai sensory-to-motor synapses. Neurosci Lett, 337(1),9-12  
  34. Choi JH, Lee JA, Yim SW, Lim CS, Lee CH, Lee YD, Bartsch D, Kandel ER, Kaang BK, 2003: Using an aplysia two-hybrid system to examine the interactions between transcription factors involved in long-term facilitation in the nervous system of aplysia. Learn Mem, 10(1),40-3  
  35. Kim MJ, Chang DJ, Lim CS, Park WJ, Kaang BK, 2003: Screening of cDNA encoding secreted and membrane proteins in the nervous system of Aplysia. Korean J Biol Sci, 7(2),133
  36. Lim CS, Lee JC, Kim SD, Chang DJ, Kaang BK, 2002: Hydrogen peroxide-induced cell death in cultured Aplysia sensory neurons. Brain Res, 941(1-2),137-45  
  37. Suh SJ, Park YS, Lee YS, Cho TJ, Kaang BK, Cho NJ, 2001: Three functional isoforms of GAR-2, a Caenorhabditis elegans G-protein-linked acetylcholine receptor, are produced by alternative splicing. Biochem Biophys Res Commun, 288(5),1238-43  
  38. Lee JA, Kim HK, Kim KH, Han JH, Lee YS, Lim CS, Chang DJ, Kubo T, Kaang BK, 2001: Overexpression of and RNA interference with the CCAAT enhancer-binding protein on long-term facilitation of Aplysia sensory to motor synapses. Learn Mem, 8(4),220-6  
  39. Lee YS, Park YS, Nam S, Suh SJ, Lee J, Kaang BK, Cho NJ, 2000: Characterization of GAR-2, a novel G protein-linked acetylcholine receptor from Caenorhabditis elegans. J Neurochem, 75(5),1800-9  
  40. Myeong H, Jeoung D, Kim H, Ha JH, Lee Y, Kim KH, Park C, Kaang BK, 2000: Genomic analysis and functional expression of canine dopamine D2 receptor. Gene, 257(1),99-107  
  41. Lee YS, Lee JA, Jung J, Oh U, Kaang BK, 2000: The cAMP-dependent kinase pathway does not sensitize the cloned vanilloid receptor type 1 expressed in xenopus oocytes or Aplysia neurons. Neurosci Lett, 288(1),57-60  
  42. Chang DJ, Li XC, Lee YS, Kim HK, Kim US, Cho NJ, Lo X, Weiss KR, Kandel ER, Kaang BK, 2000: Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in aplysia sensory neurons. Proc Natl Acad Sci U S A, 97(4),1829-34  
  43. Park YS, Lee YS, Cho NJ, Kaang BK, 2000: Alternative splicing of gar-1, a Caenorhabditis elegans G-protein-linked acetylcholine receptor gene. Biochem Biophys Res Commun, 268(2),354-8  
  44. Han JH, Yim SW, Lim CS, Park CW, Kaang BK, 1999: Expression of a non-inactivating Kchannel driven by a rat heat shock promoter increased the resting potential in Aplysia silent neurons. Neurosci Res, 34(1),13-9  
  45. Lee YS, Park YS, Chang DJ, Hwang JM, Min CK, Kaang BK, Cho NJ, 1999: Cloning and Expression of a G Protein-Linked Acetylcholine Receptor from Caenorhabditis elegans. J Neurochem, 72(1),58-65  
  46. Hwang JM, Chang DJ, Kim US, Lee YS, Park YS, Kaang BK, Cho NJ, 1999: Cloning and functional characterization of a Caenorhabditis elegans muscarinic acetylcholine receptor. Receptors Channels, 6(6),415-24 
  47. Kim HK, Kaang BK, 1998: Truncated green fluorescent protein mutants and their expression in Aplysia neurons. Brain Res Bull, 47(1),35-41  
  48. Bailey CH, Kaang BK, Chen M, Lim CS, Casadio A, Kandel ER, 1997: Mutation in the phosphorylation sites of MAP kinase blocks learning-related internalization of apCAM in Aplysia sensory neurons. Neuron, 18(6),913-24  
  49. Lim CS, Chung DY, Kaang BK, 1997: Partial anatomical and physiological characterization and dissociated cell culture of the nervous system of the marine mollusc Aplysia kurodai. Mol Cells, 7(3),399-407  
  50. Kaang BK, 1996: Parameters influencing ectopic gene expression in Aplysia neurons. Neurosci Lett, 221(1),29-32  
  51. Kaang BK, 1996: Neuronal expression of reporter genes in the intact nervous system of Aplysia. Mol Cells, 6,285
  52. Zhao B, Rassendren F, Kaang BK, Furukawa Y, Kubo T, Kandel ER, 1994: A new class of noninactivating K+ channels from aplysia capable of contributing to the resting potential and firing patterns of neurons. Neuron, 13(5),1205-13  
  53. Bacskai BJ, Hochner B, Mahaut-Smith M, Adams SR, Kaang BK, Kandel ER, Tsien RY, 1993: Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science, 260(5105),222-6  
  54. Kaang BK, Kandel ER, Grant SG, 1993: Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron, 10(3),427-35  
  55. Adams SR, Bacskai BJ, Hochner B, Kaang BK, Kandel ER, Mahaut-Smith M, Tsien RY, 1993: Confocal imaging of cAMP signals in Aplysia neurons. Jpn J Physiol, 43(Suppl1),S91-3